Selected Publications:
2025
Joshua R Heyza, Mariia Mikhova, Gloria I Perez, David G Broadbent, Jens Christopher Schmidt. Dynamic chromatin tethering by MDC1 regulates genome stability. (Submitted)
Petia Adarska*, Eleanor Fox*, Joshua Heyza*, Carlo Barnaba*, Jens Schmidt, Francesca Bottanelli. Fast Antibiotic resistance- Based gene editing of mammalian cells with CRISPR-Cas9 (FAB-CRISPR). [Preprint] arXiv:2502.12675. *Co-first authors
2024
Mashayekhi F, Ganje C, Caron MC, Heyza JR, Gao Y, Zeinali E, Fanta M, Li L, Ali J, Mersaoui SY, Schmidt JC, Godbout R, Masson JY, Weinfeld M, Ismail IH. PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress. Cell Rep. 2024 Dec 24;43(12):115066.
Mikhova M, Goff NJ, Janovič T, Heyza JR, Meek K, Schmidt JC. Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells. Nat Commun. 2024 Nov 23;15(1):10159.
2023
Heyza JR*, Mikhova M*, Schmidt JC. Live cell single-molecule imaging to study DNA repair in human cells. DNA Repair (Amst). 2023 Sep;129:103540. *Co-first authors
Brambati A, Sacco O, Porcella S, Heyza J, Kareh M, Schmidt JC, Sfeir A. RHINO directs MMEJ to repair DNA breaks in mitosis. Science. 2023 Aug 11;381(6658):653-660.
Heyza JR, Mikhova M, Bahl A, Broadbent DG, Schmidt JC. Systematic analysis of the molecular and biophysical properties of key DNA damage response factors. Elife. 2023 Jun 21;12:e87086.
Heyza JR, Ekinci E, Lindquist J, Lei W, Yunker C, Vinothkumar V, Rowbotham R, Polin L, Snider NG, Van Buren E, Watza D, Back JB, Chen W, Mamdani H, Schwartz AG, Turchi JJ, Bepler G, Patrick SM. ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe. NAR Cancer. 2023 Jan 11;5(1):zcac045.
2022
VanderVere-Carozza PS, Gavande NS, Jalal SI, Pollok KE, Ekinci E, Heyza J, Patrick SM, Masters A, Turchi JJ, Pawelczak KS. In Vivo Targeting Replication Protein A for Cancer Therapy. Front Oncol. 2022 Feb 18;12:826655.
2020
Hu C, Zhang M, Moses N, Hu CL, Polin L, Chen W, Jang H, Heyza J, Malysa A, Caruso JA, Xiang S, Patrick S, Stemmer P, Lou Z, Bai W, Wang C, Bepler G, Zhang XM. The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53. Cell Death Dis. 2020 May 7;11(5):328.
2019
Heyza JR, Lei W, Watza D, Zhang H, Chen W, Back JB, Schwartz AG, Bepler G, Patrick SM. Identification and Characterization of Synthetic Viability with ERCC1 Deficiency in Response to Interstrand Crosslinks in Lung Cancer. Clin Cancer Res. 2019 Apr 15;25(8):2523-2536.